Acquired resistance to echinocandins in Candida albicans: case report and review

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Acquired resistance to echinocandins in Candida albicans: case report and review.

OBJECTIVES A patient with Candida albicans thrush and oesophagitis was treated with high doses of caspofungin but treatment eventually failed. Four C. albicans isolates were serially recovered before and after caspofungin treatment. A microbiological study was performed to characterize these four isolates. METHODS In vitro antifungal susceptibility testing was performed by the EUCAST referenc...

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A married man, 54 years of age, attended the clinic on October 17, 1955, complaining of urethral discharge, constant urethral irritation, and slight frequency of micturition of 3 days' duration. He had been in good health until the onset of these symptoms. Extra-marital coitus was denied. There was a very scanty, thin, greyish, mucopurulent urethral discharge. The glans penis and prepuce were n...

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Candida Albicans Dural Granuloma: Case Report

Candida albicans dissemination to the central nervous system (CNS) may occur in immunocompromised patients even without prior cranial surgery. In such cases, intracerebral lesions are most frequent, meningeal or cerebrospinal fluid involvement being rare. We, here, describe a case of Candida albicans granuloma developing exclusively inside the width of the dura mater, successfully treated by su...

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Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C. albicans with low levels of echinocandins stimulated chitin synthase (CHS) gene expression, increased Chs activity, elevated chitin content and reduced efficacy of these drugs. Elevation of chitin synthesis...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2007

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkm095